| Period | Intervention | Control | p-value | |||
| Existence | Non-existence | Existence | Non-existence | |||
| Arrhythmia | Baseline | 12 (24.5%) | 37 (75.5%) | 11 (23.4%) | 36 (76.6%) | 1.000 |
| 3 months | 12 (24.5%) | 37 (75.5%) | 12 (25.5%) | 35 (74.5%) | 1.000 | |
| 6 months | 11 (22.4%) | 38 (77.6%) | 12 (25.5%) | 35 (74.5%) | 0.813 | |
| 9 months | 13 (26.5%) | 36 (73.5%) | 15 (31.9%) | 32 (68.1%) | 0.655 | |
| 12 months | 13 (27.7%) | 34 (72.3%) | 13 (27.7%) | 34 (72.3%) | 1.000 | |
| 24 months | 10 (24.4%) | 31 (75.6%) | - | - | - | |
| 36 months | 9 (25.0%) | 27 (75.0%) | - | - | - | |
| Coughing at night | Baseline | 0 (0%) | 49 (100%) | 0 (0%) | 47 (100%) | - |
| 3 months | 0 (0%) | 49 (100%) | 0 (0%) | 47 (100%) | - | |
| 6 months | 0 (0%) | 49 (100%) | 0 (0%) | 47 (100%) | - | |
| 9 months | 0 (0%) | 49 (100%) | 0 (0%) | 47 (100%) | - | |
| 12 months | 0 (0%) | 47 (100%) | 0 (0%) | 47 (100%) | - | |
| 24 months | 0 (0%) | 41 (100%) | - | - | - | |
| 36 months | 0 (0%) | 36 (100%) | - | - | - | |
| Moist rale | Baseline | 0 (0%) | 49 (100%) | 0 (0%) | 47 (100%) | - |
| 3 months | 0 (0%) | 49 (100%) | 0 (0%) | 47 (100%) | - | |
| 6 months | 0 (0%) | 49 (100%) | 0 (0%) | 47 (100%) | - | |
| 9 months | 1 (2.0%) | 48 (98.0%) | 1 (2.1%) | 46 (97.9%) | 1.000 | |
| 12 months | 0 (0%) | 47 (100%) | 1 (2.1%) | 46 (97.9%) | 1.000 | |
| 24 months | 1 (2.4%) | 40 (97.6%) | - | - | - | |
| 36 months | 0 (0%) | 36 (100%) | - | - | - | |
| Ankle edema | Baseline | 3 (6.1%) | 46 (93.9%) | 0 (0%) | 47 (100%) | 0.242 |
| 3 months | 5 (10.2%) | 44 (89.8%) | 0 (0%) | 47 (100%) | 0.056 | |
| 6 months | 2 (4.1%) | 47 (95.9%) | 1 (2.1%) | 46 (97.9%) | 1.000 | |
| 9 months | 2 (4.1%) | 47 (95.9%) | 2 (4.3%) | 45 (95.7%) | 1.000 | |
| 12 months | 1 (2.1%) | 46 (97.9%) | 2 (4.3%) | 45 (95.7%) | 1.000 | |
| 24 months | 2 (4.9%) | 39 (95.1%) | - | - | - | |
| 36 months | 0 (0%) | 36 (100%) | - | - | - | |
| Shortness of breath | Baseline | 5 (10.2%) | 44 (89.8%) | 7 (12.8%) | 41 (87.2%) | 0.757 |
| 3 months | 3 (6.1%) | 46 (93.9%) | 10 (21.3%) | 37 (78.7%) | 0.038* | |
| 6 months | 5 (10.2%) | 44 (89.8%) | 11 (23.4%) | 36 (76.6%) | 0.104 | |
| 9 months | 3 (6.1%) | 46 (93.9%) | 12 (25.5%) | 35 (74.5%) | 0.011* | |
| 12 months | 3 (6.4%) | 44 (93.6%) | 11 (23.4%) | 36 (76.6%) | 0.041* | |
| 24 months | 3 (7.3%) | 38 (92.7%) | - | - | - | |
| 36 months | 5 (13.9%) | 31 (86.1%) | - | - | - | |